We devise a method for the accurate simulation of wound healing and skin deformation. This is based on adequate formulations modeling the underlying biological processes. Cell movements and proliferation are described by a biochemical model whereas a biomechanical model covers effects like wound contraction and the influence of the healing process on the surrounding skin. The resulting simulation framework is very efficient and can be used with realistic input parameters like those measured in biochemistry and biophysics. The accurate behavior of our approach is shown by reproducing regenerative healing processes as well as specific effects such as anisotropic wound contraction, scarring and scab formation. Its efficiency and robustness is illustrated on a broad spectrum of complex examples.
Biochemical models, cell movement, medical simulation, physically based modeling, skin simulation, wound contraction, wound healing.
This work has been partially supported by the Max Planck Center for Visual Computing and Communication (MPC-VCC) funded by the Federal Ministry of Education and Research of the Federal Republic of Germany (grants FKZ-01IMC01 and FKZ-01IM10001), and the German Academic Exchange Service (DAAD) funded by the government of the Federal Republic of Germany and the European Union. Ron Fedkiw who provided for infrastructure and the reviewers' valuable comments that improved the manuscript are gratefully acknowledged.